Ozone therapy in infertility

Infertility is a puzzle, where there is difficulty for sperm and egg to combine and form the embryos.About 80 million couples affected worldwide.WHO has defined involuntary childlessness as a disease.

Common definition : Inability to conceive

Medical definition : under age 35 , no conception after12 months of unprotected intercourse , over age 35, no conception after 6 months of unprotected intercourse, Due to diagnosed, physical abnormality of reproductive system (eg. Blocked fallopian tube) or Inability to carry pregnancy to live birth

social definition : Non – engagement in a heterosexual relationship


Infertility may be due to a single cause in either you or your partner, or a combination of factors that may prevent a pregnancy from occurring or continuing. Fortunately, there are many safe and effective therapies for overcoming infertility. These treatments significantly improve your chances of becoming pregnant.

Some common causes of Infertility


Why Infertility is increasing in the human society ?

Female Factors

  • Fertility with age:- Carrier women , Contraception is readily available , Late marriage, Less frequent intercourse, Lack of Libido, Financially unstableness Fertility factors that changes with advanced age Ovarian reserve, Menstrual cycle, Lining of the womb, Mucus secretion , Disease affecting the reproductive system, Chronic illness
  • obesity: - Irregular or infrequent menstrual cycle, Increased infertility, Increased risk of miscarriage
  • Life style factors:-Smoking, Drugs. Exposure to chemicals and pesticides, Stress. Dietary factors [Alcohol, Anti-oxidants, Caffeine, Micronutrients
  • Work –place hazards:-Working with chemicals X-ray etc.
  • Sleep Disorders :- Ladies working in shifts may have menstrual cycle problem and infertility.

Beside medical reasons, factors which impairs male’s fertility are ---

  • Age – Poor sperm motility, DNA fragmentation.
  • Temporary and life style causes
  • Emotional stress
  • Sexual issues
  • Testicular over heating
  • Substance abuse
  • Smoking
  • Malnutrition and Nutrient Deficiencies
  • Obesity
  • Bicycling
  • Genetic Factors
  • Environmental Assaults
  • Free radicals [oxidants]
  • Exposure to estrogen like hormone disrupting chemicals
  • Industrial chemicals
  • Radiation treatment
  • Medications : Anabolic Steroids, Azulfidine, Methadone, Folex, Aldactone etc
  • Use of mobile 4 hours or more than 4 hours per day will decrease the sperm count. Damage could be caused by the electromagnetic radiation emitted by handsets or the heat they generate.

Ozone therapy as a modern and viable technique in the management of infertility issues

  • Improvement of macro- and microcirculation that results in the normalization of placenta hormonogenic function;
  • Decrease in the activity of lipid peroxidation processes and simultaneous stimulation of the antioxidant defense system of human body;
  • Immunomodulating action develops particularly through a decrease in blood level of circulating immune complexes, IgM, group and Rh antibodies, increase in the phagocytic activity of neutrophiles;
  • Decrease (if available) in the hypercoagulation activity of blood;
  • Intensification of the protein-synthesizing function of liver;
  • Stimulates production of WBC’s
  • Kills viruses, bacteria, fungi and other germs
  • Helps diseased cells to get rid of toxins and harmful free radicals
  • Release of PDGF—helps in healing and repairs
  • Release of immunosuppressive cytokines TGF-B and IL-10 may inhibit inflammation
  • Proteolytic enzymes and endogenous ROS are inhibited
  • Bradykinin inflammatory PG pelease is inhibited
  • Disappearance of edema leads to improved circulation, washing away of lactic acid and pain relief
  • Ozone also helps in improving oocyte quality, reduces insulin resistance in diabetics, PCO’s, improves blood vasculature and supply to the uterus, improvs endometrial milieu, increases fertilization rates, promotes embryo transplantation, decreases the effects of endometriosis,hydrosalpinx,adenomyosis, corrects hormonal dysregulations. Thus enhancing a healthy viable pregnancy,culminating in the birth of healthy children

Ozone therapy in male infertility

• Ozone enhances the circulation of all organs including the male organs
• Stimulates the function of testicles,therefore naturally stimulates the performance
• Effectively helpful in cases of infections like leucocytospermia

Treatments in ozone therapy:

  • patients with viral infections were given Intravenous insufflation of ozonised isotonic NaCl 200 ml with the concentration of ozone 20mcg/ml.- 10-15 sessions along with topical application, rectal insufflation and minor auto injections – 5-10 sessions
  • for local infections Patients were prescribed ozonised distilled water or ozonized olive oil per os. Along with rectal and vaginal insufflations.
  • Ozone saline hydrotubation 3-5 sessions given(in tubal pathologies, endometriosis, fibroids, cysts etc..)
  • ozone minor auto injections 5-8 sessions given (in cases of presence of autoantibodies like TPO, ATA, ANA, Antiphospholipid antibodies)
  • The well-known antimicrobic properties of ozonized olive oil as found out can be successfully used in the treatment of vulvar dystrophic diseases. Ozone therapy produces not only an anti-inflammatory effect, but also improves tissue trophism, allows rejecting the use of hormonal ointments and laser therapy.
  • The use of ozone- oxygen mixture in IVF seems to bring definite advantages both for reducing FSH dosage administration and in better preparing the endometrium, improving thus the chances of implantation