Ozone therapy in obs.&Gyn.

Obstetrics and Gynaecology deals with the various aspects of reproductive health of all women and the welfare of their babies.A complete care of women from pregnancy until after delivery.

Common gynec problems encountered in gynec practice are;

  • Abnormal uterine bleeding like Menorrhagia (heavy periods)
  • Breast lump & common breast problems
  • Condyloma
  • Decreased libido (decreased sex drive) & sexual health
  • Dysmenorrhea (painful periods)
  • Dyspareunia (painful intercourse)
  • Endometriosis
  • Fibroids
  • Gonorrhea
  • Viral infections like Herpes ,HIV, HPV (human papilloma virus), HSV (herpes simplex virus, genital)
  • Incontinence
  • Interstitial cystitis
  • Lichen sclerosus
  • Osteoporosis
  • Ovarian cysts, Polycystic Ovarian Syndrome (PCOS)
  • Premenstrual syndrome (PMS)
  • Prolapse
  • Urinary tract infection
  • Bacterial and fungal infections like Vaginitis, Chlamydia, Yeast infections
  • Vulvadynia


Common obstetrics problems encountered are;

  • abruptio placentae
  • abortion
  • Asherman's syndrome
  • diabetes and pregnancy
  • ectopic pregnancy
  • haemolytic disease of the newborn
  • labour and its abnormalities
  • large for dates
  • congenital malformation of the female genital tract
  • malpresentation and malposition
  • oligohydramnios
  • placenta praevia
  • polyhydramnios
  • pre-eclampsia
  • puerperium
  • puerperal pyrexia
  • puerperal psychiatric disease
  • spontaneous abortion
  • small for dates
  • symphysis pubis dysfunction
  • trophoblastic tumours
  • termination of pregnancy (TOP)
  • vasa praevia
  • retained placenta


Role of ozone and its mechanism of action in the management of obs. And gynec problems

The therapeutic properties of ozone can be successfully used in the management of obs. and gynec problems. Owing to the capacity and the properties like improvement of macro- and microcirculation, correction of immunological status or lipid peroxidation processes, ozone therapy has proved to be effective in different pathologies:

Ozone’s mechanisms of action:

  • Owing to its high oxidating power, highly concentrated ozone used at the local level produces a bactericidal, fungicidal and viricidal effect versus the most important species of gram-positive and gram-negative bacteria, viruses, pathogenic fungi and protista;
  • The systemic effect of medium and low ozone concentrations produced by parenteral route of administration in medical conditions associated with hypoxia situations is based on the activation of the oxygen-dependent processes;
  • The ozonides resulted from the ozonolysis of unsaturated fatty acids modify cell membranes at the structural-functional level, intensify the enzymatic systems and thereby improve the energy metabolism.
  • The immunomodulating effect of ozone is based on its ability to activate the phagocytosis through the formation of peroxides and stimulation of the production of cytokines by lymphocytes and monocytes.
  • Modification of blood corpuscle membranes and fine-structure of vascular bed as well as a decrease in the viscosity properties of blood lead to an improvement of the blood micro-flow and respiratory metabolism at the tissue level. Further fundamental investigations have fully confirmed the applicability of ozone therapy in the treatment of gestational complications since it has been reliably established that the use of ozone leads to correction of basic links of the pathogenesis and the most important clinical appearances of disease:
  • Improvement of macro- and microcirculation that results in the normalization of placenta hormonogenic function;
  • Decrease in the activity of lipid peroxidation processes and simultaneous stimulation of the antioxidant defense system of human body;
  • Immunomodulating action develops particularly through a decrease in blood level of circulating immune complexes, IgM, group and Rh antibodies, increase in the phagocytic activity of neutrophiles;
  • Decrease (if available) in the hypercoagulation activity of blood; Intensification of the protein-synthesizing function of liver;
  • Ozone therapy exerts a beneficial influence on the clinical course of threatened abortion, gestosis, pregnancy anemia, fetoplacental insufficiency, reduces a risk of intrauterine fetus infection and a risk of fatness-associated pregnancy complications, improves a prognosis of these diseases;
  • Ozone therapy reduces stationary treatment time, reduces the use of medicinal agents;
  • Ozone therapy significantly reduces a risk of such complications as delivery weakness, postnatal and early postnatal bleedings;
  • The use of ozone as a component of treatment complex improves perinatal adaptation of newborn children.
  • Inflammatory diseases of pelvic organs i.e. internal genitals being considered one of the most frequent pathologies of the woman's body require a new therapeutic approach due to resistance of microorganisms to available antibiotics, high allergization of human body, immunodeficiency and metabolic disturbances associated with the basic pathology.
  • a. Ozone therapy for inflammatory diseases of pelvic organs is considered as a component of antioxidant therapy as well as exerts a corrective influence on the cellular and humoral immunity confirmed by an increase in immunoregulative index, a decrease in the level of IgM and circulating immune complexes.
    b. The addition of medical ozone to the multimodality therapy exerts a positive influence on the clinical appearances of acute inflammatory diseases of pelvic organs providing a detoxication, analgesic and sedative effect that allows considerably reducing the use of appropriate traditional medications. A decrease in relapse percentage after the use of ozone as a component of pathogenetic therapy can be seen.

Treatments in ozone therapy:

  • patients with viral infections were given Intravenous insufflation of ozonised isotonic NaCl 200 ml with the concentration of ozone 20mcg/ml.- 10-15 sessions along with topical application, rectal insufflation and minor auto injections – 5-10 sessions
  • for local infections Patients were prescribed ozonised distilled water or ozonized olive oil per os. Along with rectal and vaginal insufflations.
  • Ozone saline hydrotubation 3-5 sessions given(in tubal pathologies, endometriosis, fibroids, cysts etc..)
  • ozone minor auto injections 5-8 sessions given (in cases of presence of autoantibodies like TPO, ATA, ANA, Antiphospholipid antibodies)
  • The well-known antimicrobic properties of ozonized olive oil as found out can be successfully used in the treatment of vulvar dystrophic diseases. Ozone therapy produces not only an anti-inflammatory effect, but also improves tissue trophism, allows rejecting the use of hormonal ointments and laser therapy.